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Formulation/Analytical Development

The Pharmacology Core provides a wide range of customized services for formulation and analysis of drugs and drug targets. These include services such as solubility/formulation, specialization in lipid based and parenteral formulations, formulation scale-up to Phase I requirements, UV/Vis spectrophotometry, HPLC and LC/MS, full assay development and Good Manufacturing Practices (GMP) validation and stability programs.

Validation

The Pharmacology Core provides a wide range of assays and validation services, including custom development.



Validated Methods

Lipids:

  • Cholesterol
  • Dipalmitoylphosphatidylcholine
  • Distearoylphosphatidylcholine
  • Distearoylphosphatidylcholine
  • Distearoylphosphatidylethanolaminepoly(ethylene glycol)2000 (DSPE-PEG2000)
  • Distearoylphosphatidylglycerol
  • Distearoylphosphatidylglycerol
  • Monostearoylphosphatidylcholine
  • Sphingomyelin

Cytotoxics:

  • Cytarabine
  • Daunorubicin
  • Doxorubicin
  • Floxuridine
  • Irinotecan
  • Vincristine
  • Vinorelbine
  • 5-FU

Other:

  • Sodium Phosphate

Custom Validation Available

 


Please contact the Pharmacology Core (pharma@bcprc.ca) for more information.

 Pharmacology Service Request Form